What is gout

summary

My grandfather has been gout, there will be swollen joints, then, what is gout? Let's talk about it.

What is gout

Firstly, gout is a crystal related arthritis caused by monosodium urate (MSU) deposition, which is directly related to hyperuricemia caused by purine metabolism disorder and (or) reduced uric acid excretion. It refers to acute characteristic arthritis and chronic gout stone disease, mainly including acute onset arthritis, gout stone formation, gout stone chronic arthritis, urate nephropathy and uric acid nephropathy Urinary calculi, severe can appear joint disability and renal insufficiency. Gout is often accompanied by abdominal obesity, hyperlipidemia, hypertension, type 2 diabetes and cardiovascular disease.

Secondly, the most important biochemical basis of gout is hyperuricemia. Normal adults produce about 750 mg of uric acid every day, 80% of which are endogenous and 20% are exogenous. These uric acids enter the uric acid metabolism pool (about 1200 mg). About 60% of the uric acid in the metabolism pool is metabolized every day, of which 1 / 3 is about 200 mg by intestinal catabolism, and 2 / 3 is about 400 mg by renal excretion, so as to maintain the stability of uric acid level in the body. Problems in any link can lead to adverse reactions Hyperuricemia.

Finally, gout can be divided into primary and secondary according to the etiology. Primary gout is caused by congenital purine metabolism disorder and (or) uric acid excretion disorder on the basis of excluding other diseases; secondary gout is caused by renal disease or some drug-induced uric acid excretion reduction, myeloproliferative disease and increased uric acid production caused by tumor chemotherapy. Moreover, after suffering from gout, there will be different manifestations at the present stage. Generally, there will be no uncomfortable feeling at the initial stage.

matters needing attention

Gout disease to control their own diet, in peacetime to pay attention to weight loss, but also to drink more water, not smoking or drinking, this is not good for the disease.