The best choice of chemotherapy for small cell lung cancer

summary

Lung cancer originated from bronchial mucosa epithelium, which is called carcinoma in situ. Cancer can grow into bronchi or adjacent lung tissue, and can spread through lymphatic, bloody metastasis or directly into the bronchus. The distribution of lung cancer was more in the right lung than in the left lung. The upper leaves are more than the lower leaves. The clinical classification of lung cancer can be divided into two categories: non-small cell carcinoma and small cell carcinoma. Now let's learn whether surgery or chemotherapy is good for small cell lung cancer

The best choice of chemotherapy for small cell lung cancer

One is: small cell carcinoma accounts for about 20% of the incidence rate of lung cancer. The age of the disease is relatively mild. It is more common in men who are smokers at age 40. The size of the cells is similar to that of small lymphocytes, and is more common in the larger bronchi near the hilar. Central lung cancer is more common. Small cell carcinoma contains neuroendocrine granules.

Second, according to the degree of differentiation, poorly differentiated lung cancer, especially small cell carcinoma, is particularly sensitive to chemotherapy, followed by squamous cell carcinoma and adenocarcinoma. Chemotherapy can be used alone in patients with advanced lung cancer to relieve symptoms. Or combined with surgery and radiotherapy to improve the cure rate of the disease.

Third: the correct sequence of administration can increase the efficacy of drugs, otherwise it will aggravate the side effects! Paclitaxel + DDP, gemcitabine combined with DDP, gemcitabine before cisplatin, can enhance the curative effect. If paclitaxel is used after DDP, it can aggravate the myelosuppression. Paclitaxel + ADM (doxorubicin) and ADM combined with PTX (paclitaxel) can reduce the incidence of mucositis, VCR (vincristine) + MTX (methotrexate), VCR (vincristine) can prevent MTX (methotrexate) from flowing out of cells, which can improve the curative effect; combined with 5-FU, MTX (methotrexate) before 5-FU can increase cell killing.

matters needing attention

DM (doxorubicin), e – ADM (epirubicin): the best central venous administration, administration should be ECG monitoring, to avoid the occurrence of acute toxicity. The patient's urine will turn red, and it is forbidden to be compatible with NS, which has obvious cardiac function damage