Symptoms of drug-induced liver poisoning?

summary

The course of acute liver failure caused by paracetamol is rapid and dangerous. Often patients can be killed in a few days. From this point of view, acute liver failure and chronic liver failure are different. In foreign countries, liver failure caused by careless overdose of drugs is one of the main causes of advanced liver disease. The most common painkiller is paracetamol. Symptoms of drug-induced liver poisoning? Let's talk about it.

Symptoms of drug-induced liver poisoning?

The course of acute liver failure caused by paracetamol is rapid and dangerous. Often patients can be killed in a few days. From this point of view, acute liver failure and chronic liver failure are different. The main causes of the latter are chronic viral hepatitis, long-term drinking, fatty liver and so on. Therefore, in order to conquer acute liver failure, we must not only seize the time to treat the disease, but also take preventive measures.

Human liver is an important organ specially responsible for neutralizing and detoxifying the "suspicious" substances after digestion and absorption. Many drugs, including acetaminophen, have to pass the liver test. Only after the inactivation of liver metabolism can the drug molecules be successfully discharged from the body. For example, under normal circumstances, acetaminophen in the liver after sulfurization (combined with sulfuric acid molecules) and glucosylation, the metabolic task is over.

Acetaminophen and its metabolites do not harm the liver. However, if there is too much acetaminophen in the body and the normal metabolic channels of the liver are blocked, some acetaminophen will be forced to take the second metabolic channel, that is, the jurisdiction of cytochrome P450 system. The intermediate products produced by this second metabolic channel are different. If we can not "detoxify" in time, it will accumulate more and more in liver cells, causing damage to cell structure.

matters needing attention

The best way to prevent acetaminophen poisoning is to limit the dose. The total dosage of acetaminophen in normal people should not exceed 4000 mg per day. The dosage of acetaminophen should be reduced to 2000-3000 mg per day in patients with hepatitis and those who often drink alcohol. Patients who take other drugs for a long time should consult their doctors before taking cold analgesics to avoid taking too many liver injuring drugs at the same time.