How does Parkinson's disease come about

summary

Parkinson's disease is usually a disease of the elderly, Parkinson's disease seriously affects their lives, so we must know how to get Parkinson's disease, so as to achieve the right medicine.

How does Parkinson's disease come about

First, Parkinson's disease may be due to aging. The incidence rate and prevalence of Parkinson's disease increase with age. Parkinson's disease usually occurs over 60 years old, which suggests that aging is related to the onset of Parkinson's disease. The data show that the number of dopaminergic neurons in substantia nigra of normal adults decreases gradually with age. However, the prevalence of Parkinson's disease is not high in the elderly over 65 years old. Therefore, aging is only one of the risk factors of Parkinson's disease.

Second, Parkinson's disease may be related to genetic factors, and the role of genetic factors in the pathogenesis of Parkinson's disease has been paid more and more attention by scholars. Since the discovery of α - synuclein, the first Parkinson's disease pathogenic gene in the late 1990s, at least six pathogenic genes have been associated with familial Parkinson's disease. But only 5-10% of Parkinson's disease have family history, most of them are sporadic cases. Genetic factors are only one of the causes of Parkinson's disease.

Third, Parkinson's disease is not only related to aging and genetic factors, but also brain injury, smoking, drinking coffee and other factors, which may increase or decrease the risk of Parkinson's disease. Smoking is negatively correlated with Parkinson's disease, which has been consistent in many studies. Caffeine has a similar protective effect. Severe brain injury may increase the risk of Parkinson's disease.

matters needing attention

Parkinson's disease must be found and treated early, so as not to miss the best opportunity for treatment. At the same time, people with Parkinson's disease must pay attention to rational drug use.