What causes gastric cancer

summary

Gastric cancer is one of the most common malignant tumors in China. The incidence rate of gastric cancer is the first in the digestive tract cancer. About 170 thousand people die from gastric cancer every year. It is a disease which seriously threatens people's health. Gastric cancer can occur at any age, but most of them are 40-60 years old, male more than female. Canceration is more common in antrum, especially in lesser curvature. The average life span of untreated patients was about 13 months. The causes of gastric cancer are very complex. It is very important for us to understand the pathogenesis of gastric cancer.

What causes gastric cancer

First: dietary factors: the possible dietary carcinogenic factors are frequent consumption of smoked, baked food (containing benzopyrene) or pickled food, pickled vegetables (containing N-nitroso compounds). In recent years, studies have proposed protective factors, such as milk, animal protein, fresh vegetables and some fruits. Epidemiological studies show that eating more fresh fruits and vegetables can prevent the occurrence of gastric cancer.

Second: Helicobacter pylori infection: in recent years, it is generally believed that Helicobacter pylori infection is related to gastric cancer. HP is involved in the occurrence of gastric cancer, and its mechanism is multifaceted. HP metabolism can produce some toxic substances, such as urea, phospholipase, etc. in addition, HP infection causes gastric mucosal inflammatory cell infiltration, leading to DNA damage and apoptosis. Apoptosis stimulates epithelial cell proliferation or leads to gastric mucosal atrophy, which is the main link of gastric cancer.

Third: genetic factors: family clustering tendency of gastric cancer, and the incidence rate of gastric cancer among family members is 2~4 times higher than that of the general population. The incidence rate of gastric cancer may vary among different blood groups of ANO, and there is also a difference between different races. Some people have a higher incidence rate of gastric cancer than A in other types of blood. The data suggest that genetic factors play an important role in the pathogenesis of gastric cancer. The incidence of gastric cancer is 20%.

matters needing attention

Other factors: a large number of survey data show that social, economic, geographical, psychological and dietary behavior and habits play a certain role in the incidence of gastric cancer. High salt diet and smoking are also related. It has been reported that the content and proportion of chromium, cobalt, selenium, copper and manganese in blood, hair and tissues of patients with gastric cancer have changed, which may be related to the soil, but there is no definite data on the dose effect relationship.