What is the cause of alcoholic liver disease

summary

One of our colleagues has not come to work for a week because of alcoholic liver disease. After work today, we decided to visit him in the hospital to see if the situation is serious. Let's talk about the causes of alcoholic liver disease.

What is the cause of alcoholic liver disease

First: drinking. The liver is a large detoxification organ of human body. More than 90% of alcohol is metabolized in the liver after drinking. This is also the cause of alcoholic liver. After dehydrogenation or oxidation to acetaldehyde, a small amount of ethanol enters mitochondria and is dehydrogenated into acetic acid, which is degraded into water and carbon dioxide in peripheral tissues. That is, after detoxification and metabolism by the liver, it becomes a non-toxic substance and is discharged from the body.

Second: malnutrition. Long term drinking can lead to the weakening of the function of pancreas and small intestine and the disturbance of digestion and absorption. Due to the reduced absorption of antioxidants in food, the increase of Pro oxide production and the decrease of antioxidants in the body, it is easy to cause oxidative stress, further aggravate the damage and death of liver cells, resulting in malnutrition.

Third, some alcoholic liver disease is also inherited. There are gene polymorphisms in enzymes and cytochrome involved in ethanol metabolism, that is to say, individual differences in ethanol metabolism rate are related to gene regulation, but specific genetic markers have not yet been determined, and gender is the most important factor. The activity of alcohol dehydrogenase in gastrointestinal tract of female is lower than that of male, so the metabolism of alcohol is lower than that of male, and the concentration of alcohol in blood is higher than that of male.

matters needing attention

There are many causes of alcoholic liver disease. The above is just a brief introduction. For patients with alcoholic liver disease, they must be alcohol free and strictly control the intake of alcohol. In addition, they should pay more attention to their eating habits.