Ed virus infection symptoms?

summary

Epstein Barr virus (EBV) is a member of lymphotropic virus of herpesvirus family, whose genome is DNA. Epstein Barr virus (EBV) can specifically infect human and some primate B cells in vitro and in vivo. Human is the host of Epstein Barr virus infection, which is mainly transmitted through saliva. Asymptomatic infection mostly occurs in children, more than 90% of 3-5-year-old children have been infected with Epstein Barr virus, and more than 90% of adults have virus antibodies. Ed virus infection symptoms? Let's talk about it

Ed virus infection symptoms?

Infectious mononucleosis is a kind of acute lymphoproliferative disease, which is more common after the initial infection of EBV in adolescence. Its clinical manifestations are fever, pharyngitis, lymphadenitis, splenomegaly, abnormal liver function, and a large number of monocytes and heterotypic lymphocytes in peripheral blood. After acute phase, low fever and fatigue can last for 6 months. The prognosis of normal people is good, and the patients with immunodeficiency may die.

Childhood malignant lymphoma in Africa is also known as Burkitt lymphoma. Most of them are found in children aged 5-12 years old. They are endemic in tropical areas of Central Africa. The most common sites were face and palate. EBV DNA and nuclear antigen can be detected in the biopsies of Burkitt's lymphoma.

Nasopharyngeal carcinoma (NPC) is a common epithelial malignant tumor closely related to EBV. The incidence of NPC is high in South China (Guangdong, Guangxi, Fujian, etc.) and Southeast Asia. Epstein Barr virus DNA and nuclear antigen could be detected in nasopharyngeal carcinoma biopsies; The serum also contained high titer of VCA IgA or eaiga antibodies specific to Epstein Barr virus.

matters needing attention

Vaccine is the most effective way to prevent EBV infection, but the recombinant vaccine developed in China is under observation. At present, there is no effective antiviral drugs for EBV infection. Acyclovir can reduce the excretion of EBV from the pharynx, but it can not improve the symptoms of infectious mononucleosis. It is also ineffective in the treatment of EBV lymphoma in immunodeficient patients.