What index is thalassemia

summary

No matter what kind of disease they suffer from, they are generally judged only after some indicators exceed the value. Many human bodies are controlled by genes. Thalassemia can be caused by some gene mutations or deletions. Now let's talk about what indicator is thalassemia.

What index is thalassemia

First, the molecular structure and synthesis of globin chain are determined by genes. γ. δ, ε and β globin genes constitute the "β gene family", and ζ and α globin constitute the "α gene family". Normal people inherit two alpha globin genes from both parents to synthesize enough alpha globin chains, and inherit one beta globin gene from both parents to synthesize enough beta globin chains. Due to the deletion or point mutation of globin gene, peptide chain synthesis disorders lead to the disease.

Second, the molecular pathology of β - thalassemia is very complex. There are more than 100 kinds of β - gene mutations, mainly due to gene point mutation, and a few are gene deletion. Most of α - globin deficiency anemia is caused by α - globin gene deletion, and a few are caused by gene point mutation. White gene deletion, a few caused by gene point mutation.

Third: peripheral blood showed small cell hypochromic anemia, red blood cell size, central light staining area expansion, abnormal shape, target shape, fragmented red blood cells and nucleated red blood cells, stippled red blood cells, polychromatic red blood cells, Ho Chou's body, etc.; reticulocyte normal or increased. In the bone marrow, the proliferation of red blood cell system was obviously active, with the majority of middle and late erythroblasts. The change of mature red blood cells was the same as that of peripheral blood, and the osmotic fragility of red blood cells was significantly reduced.

matters needing attention

Generally speaking, the appearance of thalassemia will make the size of human red blood cells vary, gradually abnormal. The osmotic pressure of cells will also change under certain conditions. Thalassemia should also cause the attention of the majority of patients, once the index is found abnormal trend, we should go to the hospital to do the corresponding examination.