How to treat breast hypertrophy in precocious children?

summary

Primary precocious mammary hypertrophy is also called true precocious mammary hypertrophy or constitutional precocious mammary hypertrophy. Clinical can not find organic causes, patients before puberty and normal sexual maturity as early as the establishment of the "hypothalamus pituitary ovary axis" normal secretion function, research found that such children's sex hormone secretion often significantly increased, such as estrogen, androgen and 17 corticosterone urine output, all reach the level of normal adults. How to treat breast hypertrophy in precocious children? Let's talk about it

How to treat breast hypertrophy in precocious children?

Gonadotropin releasing hormone analogue (grh-a): this kind of drugs can inhibit the release of pituitary gonadotropin through the reverse regulation of receptor, so it has therapeutic effect on primary precocious puberty. Buserelin is commonly used, 2-3 times a day, 100mg each time, nasal inhalation. Continuous application for half a year to two years

Megestrol acetate (megestrol acetate): 6-8mg / D, twice a day, until the secondary sexual symptoms subside. After laboratory examination, it is gradually reduced to 4mg / D, twice a day.) Sex knowledge education: children should be educated about sex knowledge and menstrual health knowledge to relieve psychological changes such as inferiority and shame, and tell children that the disease is a precocious disease with good prognosis.

Medroxyprogesterone (medroxyprogesterone): a highly effective progesterone, can inhibit the secretion of pituitary gonadotropin, resulting in amenorrhea, breast atrophy, vaginal smear cytological examination showed that ovarian function decreased. Intramuscular injection: intramuscular injection of long-acting medroxyprogesterone 150-200 mg every 10-17 days; Oral administration: medroxyprogesterone tablets, 10-30 mg / D (4 mg per tablet). The treatment plan is made according to the severity of the disease and whether the symptoms are controlled or not.

matters needing attention

Minimize the impact of sex hormones in the environment: such as pollen, honey, royal jelly, chicken embryo, silkworm chrysalis; Fast growing animal food, off-season fruits, soybeans and their products, adult supplements such as snow clam, Cordyceps sinensis, ginseng, some oral liquid touted to make children "grow tall and strong", high hormone food such as poultry neck, fried food, etc.