What condition suffers from membranous nephropathy

summary

I suffer from secondary membranous nephropathy, the cause of which is directly related to my regular use of ibuprofen and diclofenac. The manifestation of this disease is somewhat hidden, so it is very important to find out the condition in time for treatment. Let's take a look at the situation of membranous nephropathy.

What condition suffers from membranous nephropathy

First of all, membranous nephropathy is a pathomorphological diagnostic term, which is a common cause of adult nephrotic syndrome. Its characteristic pathological change is the deposition of a large number of immune complexes on the epithelial side of glomerular capillary loop. The clinical manifestations were nephrotic syndrome (massive proteinuria, hypoproteinemia, high edema, hyperlipidemia), or asymptomatic proteinuria in non nephrotic range.

Secondly: idiopathic membranous nephropathy is mostly associated with anti phospholipase A2 receptor antibody. Anti phospholipase A2 receptor antibody combines with the corresponding antigen on podocytes to form in situ immune complex, and then activates complement through bypass pathway to form C5b-9 membrane attack complex, which damages podocytes, destroys glomerular filtration barrier and produces proteinuria.

Finally: secondary membranous nephropathy secondary to many systemic diseases, such as systemic lupus erythematosus, rheumatoid arthritis, hepatitis B virus infection, as well as drugs, poisons, tumor or environmental factors, the drugs causing secondary membranous nephropathy mainly include some gold preparations, mercury, penicillamine, ibuprofen, diclofenac, etc.

matters needing attention

Keep defecation unobstructed, defecate 2-3 times a day is appropriate, do not stay up late, control sex life, pay attention to rest, avoid cold. At the same time, we should also know the symptoms of membranous nephropathy, and treat it in time when we find abnormalities.