What does connective tissue disease have?

summary

Connective tissue disease refers to connective tissue involvement, including lupus erythematosus, rheumatoid arthritis, scleroderma, dermatomyositis, polyarteritis nodosa, Wegener granuloma, giant cell arteritis and Sjogren's syndrome. What does connective tissue disease have? Let's talk about it

What does connective tissue disease have?

Connective tissue disease (CTD) has some common clinical, pathological and immunological features, such as multiple system involvement (skin, joint, muscle, heart, kidney, hematopoietic system, central nervous system, etc.) with long course and complex condition, accompanied by fever, arthralgia, vasculitis, rapid erythrocyte sedimentation rate (ESR), and so on γ Globulin increased, etc; But each has its own characteristics.

Some of these autoantibodies are specific markers of diseases, and their antigens are intracellular macromolecular complexes or particles such as nucleosome, nucleolus, small nuclear ribonucleoproteins (snRNPs), centromere antigens, mitochondria and heteroribonucleoproteins (HN RNP). A variety of factors such as B cell hyperactivity, T cell dysfunction and HLA susceptibility may induce autoantibodies.

Rheumatoid factor is often positive, the titer is often increased, ESR is often increased, and some patients have diffuse hypergammaglobulinemia. Some patients had mild to moderate reduction of serum complement. Serum creatine kinase and aldolase are usually increased in patients with active myositis. Some patients had moderate anemia and decreased white blood cell count.

matters needing attention

Connective tissue disease should pay attention to improve protein content, seafood, animal viscera should eat less, choose food rich in vitamin E, C, a, B and other rich vegetables and fruits, such as radish, bean sprouts, onion, fungus, dried fruit (chestnut, walnut, almond, sunflower seed) and strawberry, plum, banana.