What is the reason of high testosterone

summary

Compared with high testosterone, everyone's understanding of the starting point is different. Many women do not understand this problem very well. As we all know, they do not have their own concept of high testosterone. What kind of situation is high testosterone.

What is the reason of high testosterone

First: women in normal circumstances, serum testosterone stable in a certain range, if more than normal, then there is the possibility of disease. In the follicular phase of normal menstrual cycle, the average serum testosterone concentration is 0.43ng/ml, and the upper limit is 0.68ng/ml. If it exceeds 0.7ng/m1 (equal to 2.44nmol / L), it is called hyperandrogenemia or hyperandrogenemia.

Second, ovaries and adrenal cortex can synthesize cholesterol from acetic acid, or absorb cholesterol from blood as matrix to synthesize steroids and secrete them into blood circulation. The main androgens in blood circulation are dehydroepiandrosterone sulfate, dehydroepiandrosterone, androstenedione, testosterone and dihydrotestosterone. The high testosterone blood sickness, namely is these several kinds of hormones, especially the testosterone in the blood content excessively high forms.

Thirdly, polycystic ovary syndrome (PCOS) is the most common cause of testosterone elevation, accounting for about 34%, followed by adrenocortical hyperfunction (29%). Thirdly, it can be seen in follicular membrane hyperplasia and adrenocortical hyperplasia. In addition, it can stimulate the nest to secrete a large amount of androgen during hyperinsulinemia, resulting in hyper testosterone. About 28% of the cases are of unknown origin.

matters needing attention

The reason of high androgen in serum is mostly due to excessive secretion of ovary or adrenal cortex; it may also be caused by abnormal peripheral transformation; it is due to the disorder of enzyme system in the process of steroid hormone biosynthesis, such as the lack of aromatase, androstenedione can not be converted into estrone, and testosterone can not be converted into estradiol, resulting in excessive accumulation of androstenedione, especially testosterone; About 38% (mainly androstenedione) is bound to albumin. Free testosterone accounts for only 2%, but it is active. What about girls with high testosterone? If tebg combined with estradiol increases and combined with testosterone decreases, free testosterone in blood increases; Hyperinsulinemia caused by insulin resistance can stimulate ovaries to secrete a large amount of androgen.