What are the symptoms of aspirin intolerance triad?

summary

Aspirin intolerance triad, or wiolar syndrome, is an unexplained respiratory hyperresponsiveness disease. Such patients are often accompanied by nasal polyps and bronchial asthma. Aspirin, indomethacin and other non steroidal anti-inflammatory drugs, often can induce rhinitis (sneezing, runny nose), asthma attacks, but also accompanied by urticaria, vascular hematoma and other symptoms. What are the symptoms of aspirin intolerance triad?

What are the symptoms of aspirin intolerance triad?

At the beginning of the disease, it is often vascular motility. Patients may have more watery nose, eosinophils in nasal secretions, hypertrophic sinusitis and nasal polyps, and asthma may occur after middle age. After taking antipyretic analgesics such as aspirin, patients can often induce rhinitis or asthma attacks. A few patients can have serious reactions, such as chest tightness, laryngeal infarction, and even shock and death.

According to the clinical manifestations, the disease has the following characteristics: 1; ② Nasal polyps are easy to recur after operation; ③ Asthma is severe and often adrenocortical hormone dependent; ④ Food pigment additives (tartrazine) and preservatives (benzyl alcohol) also often cause asthma attacks and aggravate nasal polyps.

Therefore, the following principles should be followed: ① it should be carried out when the patient's asthma is relieved. ② By experienced respiratory physicians in emergency conditions. ③ The challenge dose started from 3mg, every 3 hours, until 650mg, three times a day. The lung function should be measured after each challenge. When FEV decreases by more than 25%, it will not be challenged. ④ For those who have provided a clear history of aspirin intolerance, this examination should not be performed again.

matters needing attention

The incidence rate of this disease is more common in adults. Because patients often visit their medical departments and Department of ENT according to their own symptoms, the prevalence figures of different reports are not consistent. Poole et al. (1985) provided a set of figures for otolaryngology department. About 20% of patients with nasal polyps were intolerant to aspirin, 30% - 40% of patients with nasal polyps and asthma were intolerant to aspirin, and 10% of patients with asthma were not selected.