What is Henoch Schonlein purpura nephritis in children?

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Henoch Schonlein purpura nephritis in children is on the increase in recent years. It is an inflammatory disease of blood vessels in children caused by allergy to certain factors. The skin is red rash, which is called purpura. Kidney damage is called purpura nephritis. Let's share my experience with you.

What is Henoch Schonlein purpura nephritis in children?

Henoch Schonlein purpura (HSP) is an allergic disease associated with vascular autoimmune damage, with small vasculitis as the main lesion. It is a clinical syndrome characterized by skin purpura, hemorrhagic gastroenteritis, arthritis and glomerulonephritis. About half of HSP children have renal damage, which is called Henoch Schonlein purpura nephritis（

The basic pathological changes were IgA deposition in glomerular mesangial area, mesangial cell proliferation with or without crescent formation. Renal damage usually occurs within 3 months (95%) of skin purpura. Although it has been reported that renal damage can occur before skin purpura and 1 year after skin purpura, renal damage after 6 months should not be easily regarded as purpura nephritis.

Henoch Schonlein purpura nephritis (HSPN) is a kind of leukocyte fragmentation vasculitis, which is mainly caused by IgA immune complex deposition. The etiology of HSPN is not fully understood, which may be related to the following factors: infection, vaccination, insect bite, cold stimulation, drug allergy and food allergy. Although these factors may induce HSPN, cupping net can be used, However, it is still difficult to identify allergens in clinic, and the effect of desensitization treatment is often not satisfactory.

matters needing attention

In daily life, eat more fruits and vegetables, keep optimistic mood, pay attention not to fatigue, pay attention to the recovery of the body, in addition, if there are any symptoms should go to the hospital for examination, and corresponding treatment, these are to actively do.