What are the symptoms of acquired platelet dysfunction?

summary

Acquired platelet dysfunction, also known as secondary thrombocytopenia, is secondary to thrombocytopenia caused by other diseases, involving a considerable number of diseases. Such as drug-induced immune thrombocytopenia, other immune thrombocytopenia such as Evans syndrome, chronic lymphocytic leukemia, various acute leukemia, lymphoma, systemic lupus erythematosus, rheumatoid arthritis, hyperthyroidism, etc. What are the symptoms of acquired platelet dysfunction?

What are the symptoms of acquired platelet dysfunction?

1. Drug induced immune thrombocytopenia has a latent period before the bleeding symptoms occur. The short-term patients can get sick within a few hours after taking the medicine, and the elderly can get sick after a few months. Generally 5-10 days. Often accompanied by chills, fever, headache, nausea, vomiting, etc. Other patients with immune thrombocytopenia showed purpura, epistaxis or menorrhagia, fatigue, pale complexion and deepened urine color. Occasionally, signs of renal damage can be seen, such as hypertension, hematuria, azotemia, etc. Neurological symptoms are rare.

2、 Ineffective thrombopoiesis this disease is common in some patients with megaloblastic anemia due to vitamin B12 or folic acid deficiency. It is characterized by thrombocytopenia. Some patients have bleeding tendency, some patients have whole blood reduction, and bone marrow megakaryocytes are normal or even increased. Therefore, it is ineffective thrombopoiesis. With the treatment of thalassemia, platelets can return to normal.

3、 Thrombopoietin deficiency is a thrombocytopenia caused by congenital thrombopoietin deficiency. Most of the cases are hereditary. There are bleeding manifestations in infancy, thrombocytopenia, normal number of megakaryocytes and no special changes in morphology and structure.

matters needing attention

Because this disease thrombocytopenia is secondary, so the treatment of primary disease is key, often with the improvement of primary disease, platelet count get corresponding improvement. The etiology of this disease is complex, including poisoning, drug allergy, infection, autoimmunity, dyslipidemia, genetic factors, etc.