Symptoms of multiple sclerosis

summary

Multiple sclerosis is an autoimmune disease characterized by inflammatory demyelinating lesions of the central nervous system. The most frequently involved parts of the disease are periventricular white matter, optic nerve, spinal cord, brain stem and cerebellum. The main clinical features of the disease are scattered multiple foci of white matter in the central nervous system, remission and recurrence in the course of the disease, spatial multiple of symptoms and signs and temporal multiple of the course of the disease. Symptoms of multiple sclerosis? Let's talk about it

Symptoms of multiple sclerosis

The symptoms of shallow sensory disturbance were numbness of acupuncture on limbs, trunk or face, abnormal cold, ant walking, itching, sharp, burning pain and sensory abnormality with unclear location. The pain may be related to the demyelinating focus of the spinal nerve root, which has significant characteristics. There may also be deep sensory disturbance.

At most, about 50% of the patients' first symptoms include one or more limb weakness. Dyskinesia is more obvious in the lower limbs than in the upper limbs, and can be classified as hemiplegia, paraplegia or quadriplegia, among which asymmetric paralysis is the most common. Tendon reflexes were normal in the early stage, then developed into hyperfunction, abdominal wall reflexes disappeared and pathological reflexes were positive.

The clinical characteristics of the vast majority of patients in clinical manifestations of spatial and temporal multiple. Spatial multiple refers to the multiple lesions, and temporal multiple refers to the remission recurrence course. A few cases showed single lesion sign in the whole course of the disease. Monophasic course of disease is more common in slow progressive multiple sclerosis with spinal cord sign onset and acute multiple sclerosis with dangerous disease rarely seen in clinic.

matters needing attention

Plasma exchange (PE) PE is mainly used in MS patients who are not sensitive to high-dose corticosteroids. At present, the exact mechanism of PE treatment, the duration of curative effect and the effect on recurrence are not clear. The possible mechanism is related to the clearance of autoantibodies.