What is the cause of fetal arrest?

summary

Fetal arrest refers to the developmental arrest of the embryo in early pregnancy due to some reason. B-ultrasound examination showed that the embryo bud or fetus in the gestational sac was irregular, without fetal heart beat, or the gestational sac was withered. Clinical belongs to the category of abortion or stillbirth. So, what is the cause of fetal arrest? I'd like to share my views with you.

What is the cause of fetal arrest?

Endocrine disorders: embryo implantation and continued development depend on the coordination of complex endocrine system, any link disorder can cause abortion. During the early development of embryo, three important hormone levels are needed, one is estrogen, one is progesterone, and the other is human chorionic gonadotropin. As a mother, if her own endogenous hormone is insufficient, it can not meet the needs of the embryo, which may cause the embryo to stop breeding and abortion.

Immune factors: intrauterine embryo or fetus is allogeneic transplantation, because the fetus is the combination of parents' genetic material, and it can not be exactly the same as the mother. Maternal fetal immune maladjustment causes maternal rejection of the fetus. The common autoimmune diseases are systemic lupus erythematosus, scleroderma, mixed connective tissue disease and dermatomyositis. The second is the problem of reproductive immunity. If we carry certain antibodies, it may affect the development of embryos.

Chromosome problem: if the chromosome is abnormal, it will also lead to early abortion due to embryo undevelopment. Chromosome abnormalities include quantitative and structural abnormalities, which can be divided into aneuploid and polyploid. The most common abnormal karyotype is triploid, and trisomy 16 accounts for 1 / 3, which is often fatal. Therefore, the key to prevent fetal arrest due to chromosomal abnormalities is to regulate the body of both husband and wife, make their viscera function normal coordination, balance yin and Yang, choose the best and get pregnant, and stay away from the bad environment.

matters needing attention

The changes of physiological state during pregnancy lead to great changes in the absorption, distribution and excretion of therapeutic drugs and various environmental harmful substances. At the early stage of development, embryos are extremely sensitive to the effects of therapeutic drugs and environmental factors. At this time, all kinds of harmful factors can lead to embryo damage or even loss.