Can different blood groups be transplanted with bone marrow

summary

In our daily life, there are many diseases that need bone marrow transplantation, but bone marrow transplantation also has certain conditions. Now I would like to share with you whether bone marrow transplantation can be used in different blood groups?

Can different blood groups be transplanted with bone marrow

First of all, the MHC gene encodes the expressed antigen, which is involved in the control of immune recognition and the interaction between cell subsets. Therefore, HLA mismatch has an impact on the mutual rejection between the graft and the recipient tissue.

Second, allogeneic bone marrow transplantation (BMT) has achieved great success in clinical application since 1970s. It requires allogeneic bone marrow from siblings matched with the patient's human leukocyte antigen (HLA) and a very small number of unrelated donors, or bone marrow transplantation between family members such as parents and children, and bone marrow from unrelated donors not well matched with the patient's HLA. Although non siblings are HLA matched, they are prone to graft versus host disease (GVHD), especially in the latter case.

Finally, blood type and bone marrow are closely related, if the blood type is different, the patient's body will cause a certain rejection of bone marrow, so there is no way to fit.

matters needing attention

When choosing the operation of bone marrow transplantation, we must choose people with the same blood group for bone marrow transplantation, because the antibodies in each person's body are different, which will cause rejection to different blood groups, and even the probability of death.