Is there any way to drink without red noodles?
summary
How is drinking blush to return a responsibility? It is common for people to blush when they drink at the wine table. The reason for the reaction is that there is a genetic defect in the enzyme that metabolizes alcohol, which leads to the accumulation of toxic acetaldehyde in the body, causing vasodilation and blushing reaction. People who blush also drink alcohol, which increases the risk of fatal esophageal cancer. Follow me to learn how to drink and blush!
Is there any way to drink without red noodles?
There are two kinds of enzymes in the human body that can produce effects on alcohol. One is called alcohol dehydrogenase, which can quickly convert alcohol into acetaldehyde. People with a large amount of this enzyme in the body can often blush in a short time after drinking. Another kind is called aldehyde dehydrogenase. People who drink and blush only have the former enzyme, but not the latter one. Therefore, the body accumulates aldehyde rapidly and cannot metabolize it. Therefore, when they blush for a long time, they can only expect the P450 (a group of enzymes with low specificity) in the liver to metabolize the alcohol slowly.
The lack of aldehyde dehydrogenase in people who easily blush after drinking will lead to the accumulation of a large amount of acetaldehyde in the body, which will make the liver decompose slowly and aggravate the burden on the liver. However, compared with those who don't blush after drinking, the advantage of blushing after drinking is that as long as they have a red face and say that they have reached the limit, ordinary people will no longer persuade them to drink, and the alcohol they have consumed can be decomposed by sleeping for one night, which is not the biggest harm to human body. If you don't blush after drinking, but you lack two kinds of enzymes in your body, this kind of people tend to eat more alcohol than they can bear, and the burden on your liver will be more heavy than you think. Therefore, although it is a kind of genetic defect that people tend to blush when drinking, from another point of view, blushing can also be rescued from the endless wave of alcohol persuading. As long as you don't take the initiative to consume alcohol, the harm to your health is not very great.
In short, alcohol is first converted into acetaldehyde by the catalysis of alcohol dehydrogenase; Then, acetaldehyde becomes acetic acid under the action of aldehyde dehydrogenase 2; Then, acetic acid participates in multiple metabolic pathways in the body, and finally gets carbon dioxide and water, which are discharged from the body. Among them, in addition to ethanol itself has certain toxicity, acetaldehyde is the most harmful. It is toxic to many tissues and organs, may cause DNA damage, and is also considered to have a variety of carcinogenic effects. In animal experiments, acetaldehyde is even used as a mutagen for cancer models.
matters needing attention
Some scholars think it is allergic reaction of facial blood vessels. A small number of patients with alcohol induced flushing feel hot on their face within 5-10 minutes of alcohol absorption, and at the same time, flush, pulsatile headache, dyspnea, nausea, vomiting, sweating, thirst, chest pain, hypotension, syncope, blurred vision and mental disorder appear on their face or whole body skin. At this time, people think that they are drunk, which is called "acetaldehyde syndrome" medically, This is due to the significant increase of blood acetaldehyde level caused by ethanol oxidation metabolism.
