Does allogeneic bone marrow transplantation cause hypereosinophilia

Update Date: 2023-09-29 Source: Network

summary

For leukemia, because this disease is very serious, so patients are often advised to find a matching bone marrow for transplantation, and bone marrow transplantation for patients, there are some problems, such as rejection, let's talk about the rejection after bone marrow transplantation can cause high eosinophilia.

Does allogeneic bone marrow transplantation cause hypereosinophilia

First, there will be different degrees of rejection in the process of transplantation. One is "rejection" and the other is "graft versus host reaction". The immune system of rejection can distinguish "alien" from foreign body, attack it and exclude it. This process is called "rejection". If the donor and the recipient are related, the rejection will be weaker. If they are not related, the rejection will be heavier.

Second, graft versus host reaction (GVHD). That is, the role of immune cells in donor tissue on the recipient (host), and the host tissue antigen is also alien to the donor immune cells. The growing donor immune cells have more and more severe "attack" on the recipient, and can produce "graft-versus-host reaction".

Third: the symptoms of GVHD include fever, skin flushing, rash, hepatosplenomegaly, abnormal liver function, pancytopenia, hepatitis, severe diarrhea, bone marrow sclerosis and infection, which can be complicated with fatal reactions in severe cases. The incidence of GVHD was 1-5% in twins, 36% in relatives and 50-70% in non blood relationship. However, although GVHD is dangerous to patients, it has anti leukemia effect and can reduce the recurrence of leukemia after transplantation. In the treatment, appropriate immunosuppression can be taken.

matters needing attention

After bone marrow transplantation, if the interaction with the patient's body is good, there will be no rejection, but most patients will appear rejection after bone marrow transplantation, and the discomfort of patients after bone marrow transplantation may cause high eosinophilia, so more attention should be paid after transplantation.