What medicine does Parkinson have to treat

summary

Grandfather Liu recently felt that he was shaking when walking. He was not stable at all. He obviously felt that he was slowing down. The doctor said that it was Parkinson's disease. At present, it is not too serious. He can take some medicine for adjuvant treatment. Now let me tell you what kind of Medicine is available for Parkinson's disease.

What medicine does Parkinson have to treat

First, anticholinergic drugs can inhibit the action of acetylcholine and correct the imbalance between acetylcholine and dopamine. It is suitable for patients with early mild disease, and has certain curative effect on tremor and muscle stiffness. Amantadine: can promote the release of dopamine, and has the effect of mild activation of dopamine receptor. The usual dosage is 100 m, three times a day. It has good effect on mild disease and little side effect.

Second: dopamine replacement therapy: brain dopamine supplement is the most commonly used and effective method. Exogenous dopamine can not enter the brain through the blood-brain barrier (BBB). Levodopa, its precursor, can enter the brain through BBB and be decarboxylated into dopamine by dopa decarboxylase.

Third: dopamine receptor agonists: ergot receptor agonists (olfactory cryptic arrest and xiliangxing) are rarely used due to the risk of pulmonary and cardiac valve fibrosis. Monoamine oxidase-B inhibitor: dopamine is oxidized and degraded by MAO-B in the brain, and a large number of oxygen free radicals are produced during its metabolism to damage neurons. Therefore, inhibition of MAO-B activity can not only prolong the residence time of dopamine in the brain, enhance the curative effect, reduce the dosage of levodopa and its side effects, but also indirectly protect neurons.

matters needing attention

Parkinson's disease is a kind of senile disease, which can be treated by drugs. Several drugs commonly used in the treatment of Parkinson's disease are introduced above. Although the effect is good, it is recommended that patients should take drugs under the guidance of doctors to avoid unnecessary trouble.