What are the causes of benign fibrous histiocytoma?

summary

Suffering from benign fibrous histiocytoma is relatively lucky, why say so? Clinically, the cure rate of malignant fibrous histiocytoma is very low, which will bring great threat to the life and health of patients. However, the treatment of benign fibrous histiocytoma is simpler and the cure rate is higher. So, do you know what causes benign fibrous histiocytoma?

What are the causes of benign fibrous histiocytoma?

Common symptoms: metaphysis of long bone, persistent moderate pain and swelling are rare. So far, only a few cases have been reported, so it is difficult to make accurate statistics of gender, age and location. The disease usually occurs in adults, especially in the metaphysis of long bones. It is also found in the sacrum, ilium and mandible. The symptoms are persistent moderate pain and swelling, and patients may have persistent bone pain, especially at night.

In most cases of primary cancer, the etiology is not clear, but some cases may be hereditary. Some chromosomal abnormalities and a few rare genetic diseases are associated with cancer. In the past, cancer often occurred at the site of fracture or infection. Exposure to specific carcinogens, such as certain dyes or coatings, may increase the risk of cancer. High doses of radiation and certain chemotherapeutic drugs, especially preparations called alkylates, may be associated with some types of carcinogenesis.

The etiology of the disease is still unclear, which may be related to environmental factors, genetic factors, diet factors, mood and nutrition during pregnancy. It may also be related to trauma. Microscopically, the cells were abundant, and the collagen was arranged in a vortex or laminated pattern. The cells have round oval nuclei, which can elongate along the fiber direction. There are abundant large foamy cells that can be isolated or grouped. Multinucleated giant cells are rare and small, and mitotic figures are rare.

matters needing attention

Surgical treatment. Because benign fibrous histiocytoma is usually stage II (active) of benign tumor staging, curettage can be used in combination with local adjuvant; If resected thoroughly, it can be cured. But this disease has a certain recurrence, so the surgeon should thoroughly clean the fibrous tissue in the base during the operation to reduce the possibility of recurrence.