What are the causes of aldosterone deficiency?

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When the body's aldosterone secretion is low, aldosterone deficiency will occur, which has a great impact on the patient's body. We must find the symptoms of aldosterone deficiency in time, which can be treated in time. What are the causes of aldosterone deficiency? Next, I'd like to share my views with you.

What are the causes of aldosterone deficiency?

According to the etiology and pathogenesis, aldosterone deficiency can be divided into four categories: congenital primary aldosterone deficiency, acquired primary aldosterone deficiency, acquired secondary aldosterone deficiency, and pseudoaldosterone deficiency. Primary and secondary aldosterone deficiency are divided according to the ratio of plasma renin activity (PRA) to aldosterone, The ratio of primary aldosterone deficiency was lower than normal (hyperrenin hypoaldosteronemia), while the ratio of secondary aldosterone deficiency was normal (hyporenin hypoaldosteronemia).

Acquired secondary aldosterone deficiency: it is the most common type of this disease. The main causes are various renal diseases, such as chronic glomerulonephritis, interstitial nephritis, chronic glomerulonephritis, renal amyloidosis, renal calculi, renal cysts, etc. Kidney damage caused by systemic diseases, such as diabetic nephropathy, lupus nephritis, multiple myeloma, gouty kidney, etc. Other diseases such as cirrhosis, sickle cell anemia, hemochromatosis, acute respiratory distress syndrome, etc.

Acquired primary aldosterone deficiency: the focus is in the adrenal gland. Cortical tissue is damaged for a variety of reasons, leading to adrenal cortical dysfunction. Therefore, most patients can be combined with glucocorticoid deficiency. Selective primary aldosterone deficiency is rare, autoimmune suprarenal adrenocortical insufficiency, infection (common tuberculosis), sepsis, Metastatic tumors can cause the destruction of adrenal tissue structure. Heparin can directly inhibit aldosterone biosynthesis.

matters needing attention

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