Symptoms of hairy cell leukemia

summary

Hairy cell leukemia is a rare chronic clonal B cell proliferative disease. The cytoplasm of pathological bxibao is obviously convex, like hair, so it is named as hair cell (HC). The main clinical signs of HC were splenomegaly, decrease of circulating blood cells and a large amount of HC in peripheral blood and (or) bone marrow. Hairy cell leukemia (HCl) is B-lymphocytic leukemia. There are characteristic hairy cells in peripheral blood and bone marrow, accounting for 2% of lymphocytic leukemia. Most of the patients are middle-aged and old men. Now let's talk about the symptoms of hair cell leukemia.

Symptoms of hairy cell leukemia

First, clinical manifestations: 1) asymptomatic or fatigue, weakness, abdominal fullness, bleeding and infection; 2) 85% had splenomegaly; 3) Less than 10% had superficial lymphadenopathy and 75% had deep lymphadenopathy; 4) It is often associated with systemic autoimmune diseases and can be the first; 5) Osteolytic lesion of proximal femur.

Second, it can be divided into three types: type I, type II and invasive HCl. The common main hematological manifestation is characteristic hair cells.

Third, the main indications are: 1) symptomatic enlargement of liver, spleen and lymph nodes; 2) Hemoglobin is less than 100g / L, or blood transfusion is needed; 3) Platelets less than 100 × 109 / L with bleeding; 4) White blood cells are more than 20 × 109 / L, neutrophils less than 1 × 109/l; 5) With autoimmune diseases; 6) Repeated or severe infection; 7) There are fever, fatigue, night sweats, weight loss and other symptoms.

matters needing attention

The main treatment methods are purine drugs and splenectomy, combined chemotherapy, and rituximab. Moreover, the combination of traditional Chinese and Western medicine treatment shows obvious advantages, greatly improving the complete remission rate of the disease.