Symptoms of dependence dermatitis?

summary

Glucocorticoid dependent dermatitis (GDD) is a kind of dermatitis caused by long-term repeated inappropriate external use of hormones. It is a kind of dermatitis that the primary skin lesions disappear after topical use of glucocorticoid, but inflammatory damage occurs after discontinuation of glucocorticoid. In recent years, the incidence is increasing year by year, stubborn and difficult to cure.

Symptoms of dependence dermatitis?

The change of elasticity of glycoprotein and proteoglycan in dermis weakens the adhesion between collagen fibrils and reduces the synthesis of collagen.

Hypopigmentation and pigmentation are caused by the decrease of the number of layers in the stratum corneum and the decrease of melanin migrating to the keratinocytes. Pigmentation may be related to glucocorticoid activating melanocyte to regenerate pigment.

In hormone induced rosacea like lesions, the density of Demodex follicularis increased significantly. Demodex follicularis blocked the outlet of sebaceous glands in hair follicles, causing inflammation or allergy. Strong hormone can also make sebaceous glands proliferate, leading to a unique rosacea like rash. Hormone can make hair follicle epithelial degeneration, leading to outlet blocked, acne like rash or make the original acne worse.

matters needing attention

Hormone dependence and rebound phenomenon the anti-inflammatory properties of hormone can inhibit the development of papules and reduce itching, vasoconstriction, erythema disappear, but hormone can not eliminate the cause of the disease, after discontinuation can often cause the original disease aggravation, can be manifested as inflammatory edema, redness, burning sensation, discomfort and acute pustular rash and other rebound phenomenon. This phenomenon often occurs in 2-10 days after withdrawal of hormone and lasts for several days or three weeks. Because of rebound phenomenon, patients continue to use hormone, resulting in hormone dependence.