What is the cause of Hirschsprung's disease in children?

summary

Hirschsprung's disease in children is a kind of disease that perplexes many parents. It is mainly due to the continuous spasm of the rectum or the distal colon, feces stagnated in the proximal colon, resulting in intestinal dilatation and hypertrophy. It is a common digestive tract malformation in children. Megacolon associated with enterocolitis is the most common and serious complication, especially in the neonatal period. The etiology of the disease is still unclear. It is generally believed that long-term obstruction a few days ago, secondary hypertrophy and dilatation of the proximal colon, and poor circulation of the intestinal wall are the basic causes. So, what are the causes of Hirschsprung's disease in children? Now let me introduce it to you

What is the cause of Hirschsprung's disease in children?

Reason 1: the absence of ganglion cells in the intestinal wall of Hirschsprung's disease is a kind of intramural nerve development pause, which makes the ectodermal nerve fibers unable to participate in the normal intramural nerve plexus development. The inner plexus of the digestive tract is derived from the central neural crest. The neuroblasts migrated along the developed vagus trunk to the whole wall of the digestive tract, from the head esophagus to the tail rectum.

The second reason is genetic factors. Hirschsprung's disease is inherited in families. Since then, more and more reports about Hirschsprung's disease have been reported. With the in-depth study of genetics, it is recognized that Hirschsprung's disease is a combination of genetic and environmental factors.

Reason 3: in fact, the main lesion of Hirschsprung's disease is in the spasmodic segment. In most cases, the segment without ganglion cells is located in the distal part of rectum and sigmoid colon. In some cases, it affects the whole colon, terminal ileum or only in the distal part of rectum. During the neonatal period, the whole colon and even the small intestine are extremely dilated due to the spasm of the diseased segment of the intestine, and the symptoms of complete intestinal obstruction appear repeatedly. The older the age is, the more obvious and limited the colon hypertrophy and dilation is.

matters needing attention

Hirschsprung's disease in children is due to the continuous spasm of the rectum or distal colon, feces stagnated in the proximal colon, resulting in intestinal dilatation and hypertrophy, which is a common gastrointestinal malformation in children. Colon associated enterocolitis is the most common and serious complication, especially in the neonatal period.