What diseases are caused by immune-mediated kidney disease?

summary

Immune mediated kidney disease refers to the disease of glomerular, vascular and tubulointerstitial damage caused by the abnormal immune function of the body. It is an immune response stimulated by antigen, and there are many kinds of related antigens. These antigens can be divided into renal and non renal according to whether they come from intrarenal or extrarenal sources; It can also be divided into self antigen and foreign antigen (endogenous or exogenous to human), but the cause of antigen is often unclear. What diseases are caused by immune-mediated kidney disease? Let's talk about it

What diseases are caused by immune-mediated kidney disease?

There may be edema, hypertension, hematuria, proteinuria, renal tubular dysfunction and renal dysfunction. Clinically, there are different manifestations due to different immune injury: necrotic injury, such as acute cytotoxic injury in anti glomerular basement membrane disease, can cause obvious hematuria

The damage of immune complex type (such as glomerulonephritis after streptococcal infection) is related to hematuria and erythrocyte tubular type; Hematuria, leucopenia, erythrocytic casts and epithelial casts are associated with active systemic lupus erythematosus (SLE) and other collagen vascular diseases;

Membranous proliferative glomerulonephritis and membranous glomerulonephritis were associated with proteinuria; Hematuria often occurs in membranoproliferative glomerulonephritis; However, hematuria is rare in membranous glomerulonephritis; Minimal change and focal sclerosing glomerulonephritis can only have proteinuria.

matters needing attention

Obvious hematuria, proteinuria and edema, or severe hypertension, or short-term changes in renal function, should rest, avoid fatigue. Sodium intake should be controlled in patients with edema and hypertension (2-3 g per day). The patients with large amount of proteinuria and normal renal function should be supplemented with animal protein with high biological potency, such as eggs, milk, fish and lean meat. In patients with renal dysfunction (endogenous creatinine clearance rate < 30ml / min), the appropriate amount of protein was limited to 0.4-0.6g/kg per day.