Rett syndrome symptoms?

summary

Rett syndrome is a serious disease affecting the development of children's psychomotor development. The incidence rate is 1/10000-1/15000 girls. The clinical features were progressive mental decline, autistic behavior, hand disuse, stereotyped movement and ataxia. Its etiology and genetic mode are still unclear.

Rett syndrome symptoms?

The clinical manifestation of Rett syndrome has a certain stage, and is related to age. It can be divided into four stages: stage I: from 6-18 months of onset, lasting for several months. It is characterized by developmental stagnation, head growth retardation, no interest in play and surrounding environment, and low muscle tension.

Stage II: from the age of 1-3 years, lasting for several weeks to months. It is characterized by rapid regression of development with provocation, hand disuse and rigid movement, convulsion, autism, language loss, insomnia and self abuse.

Stage III: from the age of 2 to 10 years, lasting for several months to several years, showing severe mental regression or obvious mental retardation, and improvement of autism. Convulsions, typical rigid hand movements, obvious ataxia, body dysfunction, increased reflexes, limb stiffness, apnea when awake, good appetite but weight loss, early scoliosis, tooth biting.

matters needing attention

Stage IV: over 10 years old, lasting for several years, showing signs of upper and lower motor neuron involvement, progressive scoliosis, muscle disuse, rigidity, atrophy of both feet, loss of ability to walk independently, growth retardation, inability to understand and use language, recovery of eye to eye communication, and decrease of convulsion frequency.