Causes of rheumatoid arthritis

summary

Recently, I don't know what's wrong. I feel uncomfortable all over the body, and the swelling and pain of lower limb joints are very inconvenient to move. Sometimes I feel pain. If it's serious, I can't walk. I went to check it before I know it's rheumatoid arthritis. After treatment, my condition has been controlled to a certain extent. Now let me share with you the causes of rheumatoid arthritis.

Causes of rheumatoid arthritis

First. Genetic factors: incidence rate of rheumatoid arthritis in some families is high. In the crowd survey, we found that human leukocyte antigen (HLA) -dr 4 is related to RF positive patients. HLA study found that DW 4 was associated with RA, and 70% of the patients were HLA DW 4 positive. The patients had susceptibility genes of this point, so heredity may play an important role in the pathogenesis of RA.  

Second, immune factors: some experts believe that the onset of rheumatoid arthritis is due to the invasion of infectious agents (bacteria, viruses, mycoplasma, etc.) into the joint cavity, and the use of pathogens as antigens to stimulate plasma cells in synovium or local drainage lymph nodes can produce specific immunoglobulin G antibody. After the formation of antigen antibody complex, the antibody will be transformed into allogeneic, and then stimulate plasma cells to produce new antibodies, which is rheumatoid factor and the high risk factor of rheumatoid arthritis. 　

Third, environmental factors: Generally speaking, cold, humidity, fatigue, mental trauma, malnutrition, trauma, etc., are often the inducing factors of the disease. According to the statistics of 100 patients with rheumatoid arthritis, most of them were induced by cold (42%) and damp (27%). In addition, there were infection (10%), trauma (8%) and no obvious inducement (13%).

matters needing attention

Pay attention to avoid humid environment. Joints should pay attention to keep warm, do not wear wet clothes, shoes, socks and so on. Summer heat, do not be greedy cold dew, drink cold drinks, etc. In autumn, the climate is dry, but the autumn wind is cool and the weather turns cool, so we should prevent the invasion of wind cold. The winter wind is biting, so it's important to keep warm.