What does endotoxemia examination have?

summary

Endotoxemia is a pathophysiological manifestation caused by the release of a large amount of endotoxin into the blood by bacteria in the blood or in the lesion, or the infusion of a large amount of endotoxin contaminated liquid. Endotoxemia can be divided into endogenous and exogenous. So what are the tests for endotoxemia?

What does endotoxemia examination have?

The clinical manifestations were acute chills, chills, high fever, increased leukocytes and neutrophils. But not limited to a certain system or found that multiple systems have migratory inflammation and cause multiple organ dysfunction. There was a history of infection before the disease. In particular, the possibility of endotoxemia should be considered in patients with basic diseases which seriously affect the body's defense function, and who can not control fever and other signs of systemic infection with general antibiotics. If there are ecchymosis or ecchymosis on the skin and mucous membrane, or complicated with septic shock, the clinical diagnosis of endotoxemia is basically established.

）Laboratory data showed that leukocytes and neutrophils were significantly increased, and the diagnosis needed to obtain positive blood or bone marrow bacterial culture. Such as pus, pleural effusion, cerebrospinal fluid and other samples of bacteria also have reference value. Judgment of conditional pathogenic bacteria: it is better to obtain the same bacteria by multiple blood cultures, or the results of blood culture are consistent with those of pleural effusion, cerebrospinal fluid, urine, pus, etc., so as to conduct self bacteria serum agglutination test. If positive, it is helpful for diagnosis.

The new anti endotoxin therapy of specific anti endotoxin agents includes interrupting the synthesis of endotoxin, binding or neutralizing its activity, preventing its interaction with host effector cells, interfering with endotoxin mediated signal transduction pathway, etc. Therapeutic agents include endotoxin analogues, antibodies, subunit vaccines, polymyxin binding columns, recombinant human proteins, small molecule inhibitors of endotoxin synthesis and intracellular signal transduction.

matters needing attention

Anaerobe, Jinhong tablets, baicalin, gypenosides, Huanglian Jiedu Decoction, Reduqing, Artemisia annua extract, Jiedu Guben granule also play the role of endotoxemia treatment by improving the body immunity, reversing the performance of endotoxic shock, changing the hemodynamics, reducing the inflammatory products of endotoxemia, and directly neutralizing endotoxin.