What is the cause of 13 body syndrome?

summary

Trisomy 13 syndrome, also known as Patau syndrome, is the second common autosomal disease. The incidence of 1/ in newborn is 4000~10000 (female), and the incidence rate of female is higher than that of male. The incidence rate increases with the age of pregnant women. The main features of the disease are severe mental retardation, special facial features, hand foot and genital deformities, and may be accompanied by severe fatal deformities. 90% of the patients died within one year old. What is the cause of 13 body syndrome? Let's talk about it

What is the cause of 13 body syndrome?

1. Physical factors: X-ray, ionizing radiation, etc.

2. Chemical factors: chemical drugs such as antimetabolic and antiepileptic drugs, pesticides and poisons such as benzene, toluene, arsenic, etc.

3. Biological factors: infection of some microorganisms such as Toxoplasma gondii, rubella virus, cytomegalovirus, measles virus, mumps virus, etc.

matters needing attention

For high-risk pregnant women, amniotic fluid cell or chorionic cell chromosome examination can be used for prenatal diagnosis. At present, the related serum markers can be screened in the second trimester. Commonly used triple screening: alpha fetoprotein (AFP), free estriol (Fe,) and chorionic gonadotropin (hCG) detection. 50% of the children died within one month, 70% within six months and 90% within one year.