How much is danazol capsule?
summary
Danazol capsule is a gonadotropin inhibitor. It can inhibit the effect of estrogen by inhibiting the pituitary ovary axis. It can cause normal and abnormal endometrial atrophy and inactivity, leading to anovulation and amenorrhea. The effect of danazol Capsule on endometriosis, then, which people should use danazol capsule with caution?
How much is danazol capsule?
Danazol capsules are white or almost white crystalline or crystalline powder, and the main component is danazol. Because danazol capsule inhibits pituitary gonadotropin, the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) is reduced, which can directly inhibit the production of ovarian steroids. Danazol capsule acts on the estrogen receptor site of endometrial cells and has the effect of inhibiting estrogen, causing normal and abnormal endometrial atrophy and inactivity, leading to anovulation and amenorrhea, It can last for 6-8 months.
When danazol capsule is used in the treatment of endometriosis, under normal liver function, the daily dose of danazol capsule is 400-800mg, which is taken in batches for 3-6 months. If the symptoms reappear after withdrawal, the danazol capsule can be given another treatment; If the liver function is abnormal, it should be reduced or taken according to the doctor's advice. Before taking danazol capsules, we should exclude whether we are thrombotic patients, patients with heart, liver and kidney diseases, patients with abnormal genital bleeding, pregnant and lactating; In addition, patients with epilepsy, migraine and diabetes should use danazol capsules with caution. Pregnant women should not use this drug, and those who are pregnant should terminate their pregnancy.
Oral administration of this product is easy to absorb from gastrointestinal tract, T1 / 2 is about 4.5 hours. The peak plasma concentration was 200-800 ng / ml. If 200mg was given twice a day for 14 days, the plasma concentration would reach 0.25-2ug/ml. It is metabolized in liver and excreted from kidney α- Hydroxymethylethynyltestosterone and ethynyltestosterone.
matters needing attention
Danazol capsules are commonly used in clinical medicine, with small side effects and easy to use. No serious side effects have been found in clinical use. However, due to the special treatment of diseases, it is recommended that patients use danazol capsules under the guidance of relevant doctors.
