Respiratory syncytial virus infection with what medicine good?

summary

Respiratory syncytial virus infection, also known as respiratory syncytial virus infection, can make cultured cells produce characteristic fusion cells. It is a serious lower respiratory tract infection in infants, and a few may be accompanied by rash. Respiratory syncytial virus infection with what medicine good?

Respiratory syncytial virus infection with what medicine good?

It is caused by respiratory syncytial virus or fusion virus (RSV). It belongs to the RNA type of paramyxovirus with a diameter of 100-140 nm. The nucleocapsid is composed of 32 symmetrical 20hedral capsids with a capsule. It is not destroyed by ether and chloroform. Human cells, diploid cells and primary monkey kidney cells can be used to culture virus and produce special fusion cells. The virus could be detected in the cytoplasm of infected cells by fluorescent antibody technique. The disease is transmitted by respiratory droplets, with the characteristics of wide spread, high infection rate and long duration. It is spread and prevalent in all countries in the world, and has a large epidemic almost every year or every other year. It is one of the viruses causing severe lower respiratory tract infection in infants.

Respiratory syncytial virus (RSV) infection enters the respiratory tract of susceptible persons through air droplets or directly. After RSV invades the body, it first proliferates in the nasopharyngeal mucosa and causes upper respiratory tract infection. In infants and the elderly with low immune function, RSV can extend from nasopharynx to bronchi and alveoli, and then develop into severe bronchitis, bronchiolitis and pneumonia. Respiratory viruses invade the ciliated epithelial cells on the surface of human respiratory tract, replicate and spread in them, and directly damage the infected cells, causing local lesions or systemic toxic blood symptoms. For example, the direct damage of respiratory syncytial virus to ciliated epithelial cells is the least, but it can cause severe respiratory diseases in infants; The most susceptible age was the stage with the highest maternal antibody level; It is suggested that the disease may be related to immune response. The pathological changes of respiratory tract virus infection include congestion, edema, exudation and monocyte infiltration of nasal, pharyngeal and laryngeal mucosa, and some cells may degenerate, necrosis and fall off.

Inclusion bodies were found in cytoplasm or nucleus of epithelial cells. The degree of pathological changes was related to the type, type and infection site of the virus. In light cases, epithelial cells regenerate and return to normal after a few days. If the lesion involves bronchioles, epithelial cell necrosis and exfoliation may occur. There is extensive monocyte infiltration in the wall of bronchioles. Fibrin, cell debris and sticky mucus can block the lumen and cause atelectasis and emphysema. Viral pneumonia initially manifested as progressive decrease of cilia, vacuole formation of epithelial cells, followed by degeneration of epithelial cells, necrosis and collapse of alveolar parenchyma, necrosis and thickening of alveolar wall, interstitial edema and infiltration of monocytes and lymphocytes. When complicated with bacterial infection, mucosal congestion, neutrophil infiltration and mucus purulent secretion can be seen. In severe cases, lung abscess, sepsis and purulent changes of multiple organs can occur.

matters needing attention

Respiratory tract discharge should be strictly disinfected. Breast feeding can increase antibody, so breast feeding should be encouraged. 95% of the children vaccinated with live attenuated vaccine could produce neutralizing antibodies and antibodies could be detected in nasal secretions. In recent years, the newly developed temperature sensitive (TS) fission strain can be inoculated by aerosol method, which has good protective effect on children and adults with antibodies, but has no effect on children with negative serum antibodies.