What symptom does iron poisoning have?

summary

Iron poisoning is also called hemochromatosis. Hemochromatosis is divided into primary hemochromatosis and secondary hemochromatosis. The etiology of primary hemochromatosis is unknown. It is an autosomal dominant inheritance, which may be caused by the abnormal regulation of intestinal mucosal absorption of iron. In secondary cases, due to thalassemia, active bone marrow hematopoiesis, repeated blood transfusion, excessive intake of iron rich food, drinking, drugs, lack of nutrition and other causes of intestinal epithelial cell damage, iron is easily absorbed and stored in the tissue. What symptom does iron poisoning have? Next, I'd like to share my views with you.

What symptom does iron poisoning have?

First: from 30 minutes to 2 hours after taking iron by mistake, local necrosis and bleeding occurred due to the stimulating effect of iron on gastrointestinal mucosa, leading to hemorrhagic gastroenteritis. Clinical manifestations: nausea, vomiting, abdominal pain, diarrhea, hematemesis, bloody stool, severe hypotension, shock and coma. This period lasts about 4-6 hours.

Second: the next 2-6 hours is the asymptomatic period, the patient's surface phenomenon is good, at this time iron gathered in mitochondria and organs. About 12 hours after oral administration of a large amount of iron, hypoglycemia and metabolic acidosis may occur due to cell damage caused by iron. At the same time, fever, increased white blood cell count and coma may occur, and the child may have delayed shock. At this time, the serum iron may be as high as 89.5% μ mol/L（500 μ G / dl).

Third: liver and kidney damage, hepatomegaly, jaundice, abnormal liver function and even liver failure occurred 2-4 days after oral administration of iron. Hematuria, proteinuria and tubular type. After 2-4 weeks of ingestion of iron, it often remains because of scar formation. If a large amount of iron is taken orally for a long time, it may cause hemosiderosis in lung, liver, kidney, heart and pancreas, and may lead to embolism and fibrosis.

matters needing attention

1. For the sick children who mistakenly take a large amount of iron, they should take a large amount of raw egg white and milk to promote the formation of ferritin complex. The diet should be highly nutritious, light and easy to digest. Don't eat big fish, big meat and too greasy products, so as to avoid the inhibition of coke, adverse operation and insufficient nutrition. Fast spicy food, such as pepper, mustard, pepper, strong tea, coffee, cocoa and other food or drink. 2. Avoid food with high iron content; Avoid food with high phosphorus content; Avoid alkaline food.