Pituitary prolactinoma symptoms?
summary
Pituitary prolactinomas are usually divided into microadenomas (< 10 mm) and macroadenomas (> 10 mm). Microadenomas usually appear in female prolactinomas, while male prolactinomas usually have older age, larger tumor, higher prolactin level and invasive growth. Pituitary prolactinoma symptoms? Let's talk about it.
Pituitary prolactinoma symptoms?
1. Female PRL tumors are found in young women aged 20-30 years, often microadenomas. The typical clinical manifestation is amenorrhea galactorrhea infertility triad. The main symptoms of women before puberty are puberty delay, growth retardation and primary amenorrhea. After puberty, women show shortened menstruation, less or too much menstruation, delayed menstruation, decreased or absent sexual desire, loss of sexuality, absence of orgasm, copulation pain, abortion, infertility, etc. Signs can be seen breast atrophy, pubic hair loss, vulva atrophy, vaginal secretions decreased.
2. Male PRL tumor male prolactinoma is larger, more to suprasellar development, relatively rare. The main clinical manifestations are complete or partial sexual dysfunction, such as decreased libido, impotence, male breast development, male infertility, decreased sperm count, etc. The symptoms progressed slowly and were not easy to be paid attention to. At the time of treatment, they were in the advanced stage. The imaging examination showed that most of them were macroadenoma, and the nerve compression was obvious. Physical examination showed that adolescent patients may have stagnation of puberty, abnormal posture, breast development and trigger lactation, and small testis. Adults may have sparse beard, breast development and trigger lactation, rare pubic hair, and soft testis.
3. In patients with tumor compression syndrome, advanced PRL tumors and other types of pituitary adenomas, hypothalamic and parasellar tumors, due to their huge expansion to the suprasellar region, block PIF and cause hyperprl, the common local compression symptoms are headache and visual abnormalities. The cause of headache is increased intracranial pressure caused by macroadenoma, accompanied by nausea and vomiting. The incidence of headache in male patients with PRL tumor was higher than that in female patients. Some microadenomas have small space occupying lesions and headache, but the cause is not clear.
matters needing attention
The symptomatic patients should first choose drug therapy to inhibit lactation, correct hyperprolactinemia, resume menstruation, prevent adenoma formation or tumor enlargement, reduce osteoporosis, stop all kinds of drugs that cause PRL level rise, and follow up regularly.
