What disease is anti histone antibody positive?

summary

Histone is the most abundant protein in the nucleus, and its complex with DNA is called chromatin. The most basic subunit structure of chromatin is nucleosome, which is composed of 146 base pairs of DNA strand wrapped around eight histone molecules (two H2A-H2B heterodimers sandwiched between two h2-h4 heterodimers), two loops of core and outer core histone H1 and connecting DNA (about 60 base pairs). What disease is anti histone antibody positive? Next, I'd like to share my views with you.

What disease is anti histone antibody positive?

In non rheumatic autoimmune diseases, about 76% of patients with primary biliary cirrhosis are positive for anti histone antibodies, and most of them are anti-H1 antibodies. Many drugs can induce SLE like syndrome, known as drug-induced lupus erythematosus, the condition is lighter than SLE, symptoms can disappear after withdrawal. The detection rate of antihistones in patients with drug-induced lupus erythematosus is very high (> 95%). Patients with lupus erythematosus induced by procainamide,

Anti-h2a-h2b histone dimer antibodies mainly appeared in lupus patients induced by hydralazine. Anti-H2 and anti-h4 antibodies mainly appeared in lupus patients induced by hydralazine. Among the patients who took procaine amide for more than one year, the incidence of drug-induced lupus was as high as 20%; 5% - 10% of the patients taking hydralazine can induce lupus. In addition to these two drugs, propranolol, D-penicillamine, isoniazid, quinidine, propylthiouracil, chlorpromazine, acebutamol and methyldopa can occasionally induce lupus.

The diagnosis of drug-induced lupus erythematosus is strongly supported when only anti histone antibodies (and anti ssDNA antibodies) and no other antinuclear antibodies are detected. The IgG antibodies against H2A-H2B dimer are closely related to the clinical activity of the disease. Need to check the crowd: skin erythema.

matters needing attention

1. Don't eat too greasy and high protein food one day before blood drawing, and avoid heavy drinking. The alcohol content in the blood will directly affect the test results. 2. After 8 p.m. on the day before physical examination, fasting should be started for 12 hours, so as not to affect the test results.