The first choice for myasthenia gravis

summary

It is caused by the development of the disease and the deficiency of anticholinesterase drugs. The clinical manifestations were dysphagia, coughing, respiratory distress, difficulty and even stop. Physical examination showed pupil dilation, sweating, abdominal distension, normal bowel sounds and improved symptoms after neostigmine injection. So we must do a good job of the disease related work, then the treatment of myasthenia gravis preferred.

The first choice for myasthenia gravis

Treatment 1: oral or nasal administration, through mucosal induction of immune tolerance, can specifically reduce the antigen of local or systemic immune response. In order to prevent the occurrence of experimental autoimmune myasthenia gravis and inhibit the cellular and humoral immunity against acetylcholine receptor or its peptide, some scholars have given the eel or newborn mice acetylcholine receptor and its subunit A by oral or nasal mucosa before sensitization with acetylcholine receptor. In addition, intranasal administration can avoid the damage of gastric acid and pepsin to the antigen, which requires less antigen dose. A large number of experiments have confirmed that mucosal tolerance alone can only prevent the occurrence of experimental autoimmune myasthenia gravis, and can not effectively block the progress of experimental autoimmune myasthenia gravis.

Treatment 2: immune tolerance induced by dendritic cells, the use of immature dendritic cells, blocking or reducing the immune activation function of dendritic cells, can prevent autoimmune response. The dendritic cells of healthy rats were incubated with transforming growth factor - β 1 and transforming growth factor - γ in vitro, and then injected subcutaneously on the fifth day of experimental autoimmune myasthenia gravis. The results showed that immune tolerance was successfully induced, and the clinical symptoms of experimental autoimmune myasthenia gravis were significantly alleviated. The dendritic cells induced in vitro were the main cause of experimental autoimmune myasthenia gravis Treatment has brought new hope, but its mechanism of action in the treatment of myasthenia gravis is not clear. Moreover, dendritic cells in this state can only prevent the occurrence of experimental autoimmune myasthenia gravis, but can not effectively prevent the progress of the disease.

Treatment 3: Cyclosporin A, which is mainly used for anti rejection of liver, kidney and heart transplantation, can be used with adrenocortical hormone, and can also be used for the treatment of some immune diseases. Adverse reactions: elevated serum creatinine, hypertension, epidemic symptoms, etc.

matters needing attention

This disease needs to pay attention to: the nursing method of myasthenia gravis also needs to maintain a good attitude and cheer up. People in a positive state, the mood will be very happy, very happy, and happy attitude can help us develop very healthy living habits. In the face of fast-paced life, we can relax and find ways to relieve the pressure; in the face of work and study, we should make reasonable arrangements, treat it with heart, and treat it with an upward mental outlook. As the saying goes, when you feel comfortable, you are happy to do all kinds of things. You will not give yourself too much pressure and negative emotions, and you will have confidence in your future life.