What causes dry mouth

summary

Often dry mouth should be Sjogren's syndrome, for Sjogren's syndrome this disease many people do not particularly understand, in fact, Sjogren's syndrome is not uncommon in our life, so what causes Sjogren's syndrome that? In this paper, we will introduce the etiology of Sjogren's syndrome.

What causes dry mouth

Reason 1: viral factors: at present, there are at least three kinds of viruses that are considered to be related to the disease, such as Epstein Barr virus, cytomegalovirus and HIV. EBV can stimulate the proliferation of B cells and produce immunoglobulin. EBV and its DNA gene were detected in salivary gland, lacrimal gland and kidney of primary patients; Cytomegalovirus can also infect salivary glands and other tissues; Some AIDS patients may have secondary Sjogren's syndrome.

The second reason: genetic factors: the occurrence rate of HLA B8 and DR3 genes is very high in primary patients; In secondary patients, the frequency of HLA DR2 is very high, which may be related to the following functions of HLA DR2 gene.

The third reason: immune factors: including humoral and cellular immune abnormalities. Excessive humoral immunity can lead to a variety of organ specific and non-specific antibodies in the blood, such as anti salivary duct epithelial antibody, anti SSA, anti SSB, anti nuclear antibody, anti DNA antibody and so on. The abnormal cellular immunity includes the low transformation rate of phytohemagglutinin lymphocytes and the decrease of natural killer cell activity, but the most important is the change of T lymphocyte subsets, that is, the decrease of suppressive T cells.

matters needing attention

Mental stomachache, the pressure of modern work and life, so that a large number of people long-term existence of work mental pressure, irregular life, lack of sleep rest, lack of exercise, causing dry mouth.