Symptoms of pancreatic polypeptide tumor?

summary

Pancreatic polypeptide tumor is one of the endocrine tumors of digestive tract. It mainly occurs in pancreatic endocrine cells containing pancreatic polypeptide, which is very rare in clinic. Most pancreatic polypeptide tumors are located in the pancreas, especially in the head of the pancreas, less in the body and tail of the pancreas, and a few tumors are located in extrapancreatic organs. Symptoms of pancreatic polypeptide tumor? Let's talk about it

Symptoms of pancreatic polypeptide tumor?

The clinical diagnosis of this disease is difficult, because the clinical symptoms of pancreatic polypeptide tumor are few, so it is not easy to be found; In particular, other functional endocrine tumors can sometimes secrete a small amount of pancreatic polypeptide and cause corresponding symptoms, which is easy to be confused with this disease. When the patient has the above clinical manifestations and the serum pancreatic polypeptide can be significantly increased, the possibility of this disease should be suspected.

Radioimmunoassay was used to determine the plasma level of pancreatic polypeptide. If the basic PP level was normal, protein meal or pancreatin could be used for provocation test. If the PP level was significantly increased, it would also be helpful for the diagnosis of this disease. The combination of percutaneous transhepatic portal vein catheterization (PTPC) and selective intra-arterial injection of methylene blue (Sambi) is helpful for the qualitative and localized diagnosis of the disease.

Ultrasound, CT, MRI and selective Celiac Arteriography can help to understand the location, number and metastasis of tumor, but can not make qualitative diagnosis. Intraoperative ultrasound can help to find the small and deep hidden lesions of tumor. Immunohistochemical method can be used to determine the hormone in tumor. It can be seen that the content of pancreatic polypeptide in tumor tissue is significantly increased, Other pancreatic endocrine hormones are rare or absent, which is one of the important evidences of this disease.

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