What should Parkinson's disease do?

summary

Parkinson's disease is a common disease in people's life, it will affect our normal life, Parkinson's disease symptoms 8 years bilateral limb tremor, stiffness progressive aggravation, next I'll introduce Parkinson's disease should do what examination?.

What should Parkinson's disease do?

Pet functional imaging positron emission tomography (PET) diagnosis of Parkinson's disease, its working principle and method are basically similar to SPECT, at present mainly rely on brain glucose metabolism imaging, generally using 18F deoxyglucose (18FDG). Because in the early stage of Parkinson's disease, the local glucose metabolic rate of striatum is moderately decreased, and the glucose metabolic rate is further decreased in the late stage. There are many pet receptor imaging agents. Pet neurotransmitter imaging agents mainly use 18F DOPA pet (18fd-pet) and other nuclides. The basic principle is the same as SPECT. Pet can be used for the early diagnosis of Parkinson's disease, and can be used for the early diagnosis of high-risk groups of Parkinson's disease. It is an objective index to judge the severity of the disease.

Second: SPECT imaging findings (1) functional imaging through dopamine receptor (DAR): dopamine receptor is widely distributed in the dopaminergic pathway of the central nervous system, mainly in the substantia nigra and striatum system, and Dar (DL) is distributed in the corpus striatum of non cholinergic interneurons; DAR (D2) is located in the soma of dopaminergic neurons in substantia nigra and striatum. SPECT is to inject radionuclides, mainly 123i-ibzm, 131i-ibzm, and specific D2 receptor markers into the human body intravenously, and reflect the number and function of DAR receptors by the ratio of the radioactivity in the basal ganglia to that in the frontal lobe, occipital lobe or cerebellum, so as to diagnose early Parkinson's disease. If the patients were treated with dopa in the early stage, the DAR (D2) of the contralateral brain was up-regulated. The ratio of basal ganglia / occipital lobe and basal ganglia / frontal lobe in the brain of patients with Parkinson's disease in the middle and advanced stage after long-term administration of DOPA decreased. SPECT functional imaging can only detect the number of DAR receptors, which can not help to diagnose primary Parkinson's disease, but can distinguish some secondary Parkinson's disease, and can also be used as an indicator of the evolution of Parkinson's disease and drug treatment effect（ 2) Functional imaging of dopamine transporter (DAT): how dat transports dopamine (DA) remains unclear. Dat is mainly distributed in basal ganglia and thalamus, followed by frontal lobe. There is a positive correlation between dat content and the severity of Parkinson's disease. Dat in basal ganglia is decreased, which is very significant in early Parkinson's disease. SPECT was performed with 11c-win35428 and 123I β- The activity ratio of basal ganglia to cerebellum and the activity ratio of thalamus to cerebellum were detected to reflect the number of DAT in different regions of the central nervous system. In early Parkinson's disease, the number of DAT in basal ganglia decreased significantly.

Third: CT, MRI image performance. As Parkinson's disease is a degenerative disease of the central nervous system, pathological changes are mainly in the substantia nigra, striatum, globus pallidus, caudate nucleus and cerebral cortex. Therefore, CT image performance, in addition to universal brain atrophy, sometimes basal ganglia calcification can be seen. In addition to ventriculomegaly and other signs of brain atrophy on MRI, multiple hyperintense spots were often found in basal ganglia and white matter on T2 weighted images.

matters needing attention

The above are some ways to check Parkinson's disease. If you find Parkinson's symptoms, you should go to the hospital for treatment in time. A lot of patients delay the disease, so it leads to very serious consequences, timely treatment, can be treated, but also quickly, delay the disease, treatment is very difficult.