How did Wegener get granuloma

summary

These days are not very tired, every day also implies sleep, but always feel very tired, people are very easy to fatigue, and later there are a lot of discomfort symptoms, went to the hospital to do a physical examination, found that he had Wegener granuloma. Today, let me talk to you about Wegener's granuloma.

How did Wegener get granuloma

The first aspect: the discovery of antineutrophil cytoplasmic antibody (ANCA) and the study of immunopathology proved that ANCA is an autoimmune disease. More than 2 / 3 of the patients with rheumatoid factor positive also suggested that it was caused by a series of inflammatory reactions mediated by complement activation and immune complex formed by autoimmune reaction.

Second, there is considerable evidence that Wegener's granulomatosis is an autoimmune disease, and ANCA may be involved in the activation and injury of blood vessels. If WG has a strong specific relationship with anti-PR3 autoantibody, the antibody titer is related to clinical disease activity and can predict recurrence.

The third aspect: the interaction between ANCA and monocytes: ANCA can activate monocytes and increase the production of toxic oxygen group, IL-8 and MIP-1. There is no need to start before activation, but start can increase the production of toxic oxygen group mediated by ANCA.

matters needing attention

Glucocorticoids and immunosuppressants are needed for the induction of remission, maintenance of remission and control of relapse of Wegener's granuloma. For highly active and critically ill patients, symptoms can be quickly relieved in a short period of time, which should be combined with drug treatment.