What is the reason of fetal undevelopment
summary
Many people don't understand the disease of fetal underdevelopment. They must be treated in time. From the medical point of view, fetal arrest refers to the death of an embryo at a certain stage of development and its continued development. A fertilized egg is like a seed. It has to go through a series of complex and wonderful processes before it finally grows into a healthy baby. What's the cause of fetal underdevelopment.
What is the reason of fetal undevelopment
First, endocrine disorders, embryo implantation and continued development depend on the coordination of complex endocrine system, any link disorder, can cause abortion. During the early development of embryo, three important hormone levels are needed, one is estrogen, one is progesterone, and the other is human chorionic gonadotropin. As a mother, if her own endogenous hormone is insufficient, it can not meet the needs of the embryo, which may cause the embryo to stop breeding and abortion. Among them, the most common is luteal dysfunction, which can cause endometrial growth retardation and short luteal phase, thus affecting the implantation of fertilized eggs, or early pregnancy abortion. Luteal insufficiency is often accompanied by other gland dysfunction, such as hyperthyroidism or hypothyroidism, diabetes, relative androgen increase and hyperprolactinemia. These factors are not conducive to embryonic development and are closely related to abortion.
Second: immune factors: intrauterine embryo or fetus of pregnancy is allogeneic transplantation, because the fetus is the combination of parents' genetic material and the mother can not be exactly the same. Maternal fetal immune maladjustment causes maternal rejection of the fetus. The common autoimmune diseases are systemic lupus erythematosus, scleroderma, mixed connective tissue disease and dermatomyositis. The second is the problem of reproductive immunity. If we carry certain antibodies, it may affect the development of embryos. In fact, the detection of antibodies varies from hospital to hospital, and the views of doctors are also different. From our research point of view, we think that there are four influencing factors. One is antisperm antibodies. If there are any, they may resist sperm egg binding; The second is anti endometrial antibody, if there is anti endometrial antibody, it may affect the development of embryo and resist the development of embryo; the third is anti ovarian antibody, if there is anti ovarian antibody, it will affect the quality of egg; The fourth is called anti chorionic gonadotropin antibody. This hormone is actually an important hormone secreted seven days after sperm egg combination. However, if you have this antibody, you will resist the secretion of hormone, which may cause embryo abortion.
Third: abnormal uterus, the internal environment of the uterus and the overall environment of the uterus may have an impact on the embryo. The internal environment is the endometrium. If it is too thin or too thick, it will affect the implantation. The common causes of abortion are (1) congenital abnormalities of mullerian duct, including single horn uterus, double uterus, septal uterus and double horn uterus, resulting in narrow uterine cavity and limited blood supply. Abnormal uterine artery development can lead to dyssynchrony of decidualization and abnormal implantation. (2) Intrauterine adhesions are mainly caused by intrauterine trauma, infection or residual placenta tissue. It hinders normal decidualization and placental implantation. (3) Uterine fibroids and endometriosis lead to blood supply reduction, leading to ischemia and venous dilation, dyssynchrony of decidualization, abnormal implantation and hormone changes caused by fibroids can also lead to pregnancy failure. (4) congenital or traumatic cervical relaxation and intrauterine treatment with diethylstilbestrol often lead to mid-term pregnancy abortion.
matters needing attention
If the embryo is stopped, all pregnancy reactions of the pregnant mother will gradually disappear. First of all, there is no longer nausea, vomiting and other early pregnancy reactions, the feeling of breast swelling will also be weakened. Then there will be vaginal bleeding, often dark red bloody leucorrhea. Finally, there may be lower abdominal pain and embryo expulsion. The above-mentioned manifestations vary from person to person, and some even have no signs, so they directly have abdominal pain, and then miscarry, or the embryo is asymptomatic after abortion, which can be found by routine B-ultrasound examination. Most pregnant women have no obvious symptoms after fetal development, some pregnant women may see red, generally without abdominal pain, which is different from threatened abortion.
