How does acquired hyperlipoproteinemia return a responsibility?

summary

How does acquired hyperlipoproteinemia return a responsibility? Hyperlipoproteinemia refers to the increase of plasma cholesterol (TC) and (or) triglyceride (TG), which is actually the manifestation of the increase of one or several types of lipoprotein in plasma. In fact, it is a manifestation of the elevation of one or several types of lipoprotein in plasma. In recent years, it has been gradually recognized that the decrease of LDL-C (low density lipoprotein cholesterol) in plasma is also a disorder of lipid metabolism.

How does acquired hyperlipoproteinemia return a responsibility?

Through a variety of ways to carry out extensive and repeated health education, advocate scientific diet, balanced diet, regular physical exercise, prevent obesity, quit smoking, alcohol, and combine with health publicity and education of prevention and treatment of cardiovascular disease, obesity, diabetes and other chronic diseases, so as to keep the blood lipid in the population at an appropriate level. In addition, regular health check-up is also helpful to detect dyslipidemia as soon as possible and treat them in time.

Lipoproteinemia. The main causes of borderline hypercholesterolemia in human are dietary factors, such as high cholesterol, high saturated fatty acid intake and overweight caused by excessive calories, besides its high basic value, followed by age effect and female menopause（ 1) High basal plasma LDL-C (low density lipoprotein cholesterol): this high basal LDL-C is one of the main causes of borderline hypercholesterolemia in humans.

It is generally believed that the intake of saturated fatty acids accounts for 14% of the total calories (that is, 7% more), which can increase blood cholesterol by about 0. 52 mmol / L (20 mg / dl), most of which were LDL-C. Although the exact mechanism of saturated fatty acids inhibiting LDL receptor activity is not clear, it may be related to the following five aspects: (1) inhibiting the synthesis of cholesteryl ester in the liver; ② Promote the inactive non esterified cholesterol into the active pool; ③ Promote the formation of regulatory oxidative steroids; ④ The activity of LDL receptor on cell surface was decreased; ⑤ The affinity between LDL and LDL receptor was decreased.

matters needing attention

Lifestyle: the concentration of plasma triglyceride in sedentary people is higher than that in those who insist on physical exercise. Both long-term and short-term physical exercise can reduce the level of plasma triglyceride. Exercise can also increase LPL activity, HDL-C (high density lipoprotein cholesterol) level, especially hdl2-c level, and reduce liver lipase (HL) activity. Long term exercise can also increase the clearance of exogenous triglyceride from plasma.