Symptoms of carbamazepine poisoning

Update Date: 2024-12-02 Source: Network

summary

The anticonvulsant mechanism of carbamazepine is still unclear, which may be due to its ability to increase the inactivation efficiency of sodium channels, limit postsynaptic neurons and block presynaptic Na + channels, thus limiting the release of action potentials of presynaptic and postsynaptic neurons and blocking the release of excitatory neurotransmitters. Symptoms of carbamazepine poisoning? Next, I'd like to share my views with you.

Symptoms of carbamazepine poisoning

The common adverse reactions were blurred vision, diplopia, nystagmus and other central nervous system reactions, as well as dizziness, fatigue, nausea and vomiting; Most of them occurred in 1-2 weeks after medication Combined with coumarins, estrogens, cyclosporine, digitalis, levothyroxine and quinidine, this product can induce liver metabolic enzymes, accelerate the metabolism of the above drugs, reduce blood concentration, shorten half-life and weaken drug effect.

Rash, urticaria, pruritus, child behavior disorder, liver dysfunction, cholestasis, hepatocellular jaundice and hypothyroidism are rare; Rare granulocytopenia, myelosuppression, arrhythmia, allergic hepatitis, liver failure, acute renal failure and hypersensitivity of multiple organs.

FDA has published reports that carbamazepine may cause severe skin lesions in some patients, such as S-J syndrome and toxic epidermal necrolysis. Heart, liver and kidney dysfunction, atrioventricular block, severe abnormal hemogram, history of bone marrow suppression and pregnant and lactating women are forbidden.

matters needing attention

1. * it is used for glaucoma, cardiovascular disease, diabetes, patients with intolerance to tricyclic antidepressants, alcoholism, urinary retention, nephropathy and elderly people. 2. Interference in diagnosis: it can increase the test values of aminotransferase, serum bilirubin, alkaline phosphatase, urea nitrogen, urine sugar, etc; The serum calcium concentration decreased and the thyroid function test value decreased.