Multiple chondrodysplasia?

summary

Multiple cartilage dysplasia was first described by Ollier in 1899, so it is also called Ollier's disease. It is a rare non hereditary benign tumor. Most of them were asymmetrically distributed in cartilage lesions and subperiosteal deposition. It can be found in both long and short tubular bones, and it can occur in unilateral or bilateral limbs. The age of onset of multiple chondrodysplasia is usually less than 10 years old, male is more than female, the deformity is obvious in puberty, and then gradually stable. Because of the multiple lesions, it is difficult to treat every endochondroma. Asymptomatic patients can not be treated, but should be followed up. For the specific parts with symptoms, curettage and bone grafting can be done, and osteotomy can be done to correct the obvious limb deformity.

Multiple chondrodysplasia?

The tumor tissue was white, slightly glossy, brittle and translucent. There are yellow calcification or ossification areas, or myxoid degeneration areas. Under the microscope, lobulated hyaline cartilage was seen, with piles of chondrocytes. In the case of binucleate, the size of mononuclear was uniform, and the staining was not deep. Multiple cartilage dysplasia, often in childhood symptoms, to adolescence deformity obvious, after gradually stable.

Symptoms and signs: palpable mass with little pain. Tumor invasion of the hand or foot, due to multiple lesions can cause disability. The lesions invaded the long tubular bone, which made the ossification of endogenous cartilage unable to proceed normally, and the epiphyseal plate could not grow normally, so the limbs could be shortened and bent. Such as forearm to ulnar bending deformity, lower limb genu valgus and so on. When the patient reaches adulthood, the tumor can stop growing. Malignant transformation may occur in adults with multiple cartilage dysplasia. The malignant transformation rate is about 5% - 25%.

Because of the multiple lesions, it is difficult to treat every endochondroma. Asymptomatic patients can not be treated, but should be followed up. For the specific parts with symptoms, curettage and bone grafting can be done, and osteotomy can be done to correct the obvious limb deformity. It has been reported that multiple cartilage dysplasia can be replaced by normal tissue as the lesion shrinks or even disappears completely. But on the other hand, the potential malignant change of this lesion is more likely to be chondrosarcoma or osteosarcoma. If there is malignant change, it should be removed by more thorough surgery, or even amputation.

matters needing attention

X-ray examination: the X-ray manifestations of each lesion of multiple cartilage dysplasia were similar to that of single endochondroma, but multiple. And there are skeletal deformities or shortening. The metaphysis can be widened. Multiple endophytic chondromas have the potential of malignant changes, which should be paid attention to.