Early symptoms of iron poisoning?

summary

Iron poisoning is also called hemochromatosis. Hemochromatosis is divided into primary hemochromatosis and secondary hemochromatosis. The etiology of primary hemochromatosis is unknown. It is an autosomal dominant inheritance, which may be caused by the abnormal regulation of intestinal mucosal absorption of iron. Early symptoms of iron poisoning? Let's talk about it

Early symptoms of iron poisoning?

90% ～ 100% of the patients had skin pigmentation. The characteristic metallic color or slate grey is sometimes described as bronze or dark brown due to increased melanin (which leads to bronze) and iron deposition (which leads to grey pigment) in the dermis. The skin is dry, the surface is smooth and thin, the elasticity is poor, and the hair is sparse.

It occurs in 50% - 80% of patients, and is more likely to occur in patients with family history of diabetes. The patients with mild damage in the early stage may have no typical symptoms, while those with severe damage in the middle and late stage may have typical symptoms. Late complications are the same as diabetes caused by other causes. Patients without timely treatment may have complications of acute metabolic disorder, such as ketoacidosis, nonketotic hyperosmolar diabetic coma, etc.

Hepatomegaly can occur before symptoms or abnormal liver function. More than 90% of patients with symptoms can have hepatomegaly, and some of them have little laboratory evidence of liver function damage. Mild elevation of transaminase was found in 30% ～ 50% of patients. After bloodletting therapy, transaminase returned to normal.

matters needing attention

Rational use of iron supplements. Disulfide propanol is forbidden in the application of iron preparation. There are two active sulfhydryl groups in the molecule of this product, which have high affinity with metal. It can capture the metal that has been combined with the enzyme system in the tissue, form non-toxic compounds that are not easy to decompose, and excrete them from the urine to restore the activity of the enzyme system, so it has detoxification effect.