What is the life span of normal platelets?

summary

Platelets, as the main regulatory "members" of thrombosis and bleeding, its life span directly affects the curative effect and even the life of patients. Recently, I learned from Suzhou University that Professor Dai Kesheng's team from the First Affiliated Hospital of Suzhou University and Jiangsu Institute of Hematology has found the regulatory mechanism of platelet "longevity" and platelet clearance under pathological conditions, as well as the regulatory mechanism of platelet function in the process of thrombosis and bleeding. The relevant results have been published in clinical research and the Journal of the American Academy of Sciences.

What is the life span of normal platelets?

Half a century ago, it has been found that the life span of platelets in circulating blood is only 8-9 days, and the function of platelets stored in vitro is basically lost within 5 days. Even in cancer, infection, diabetes, primary thrombocytopenic Pura and other diseases, and in the process of drug treatment of some diseases, fatal bleeding is often caused by thrombocytopenia, The "culprit" is the premature elimination of platelets due to the shortened life span of platelets with unknown mechanism.

Researchers found that protein kinase A (PKA) is a regulator of platelet apoptosis homeostasis. Whether in aging or storage state, or from patients with infection, diabetes and primary thrombocytopenic purpura, platelet apoptosis occurred, and PKA activity decreased significantly. Using PKA inhibitors or in platelet conditional PKA knockout mice, we found that the decrease of PKA activity can lead to endogenous mitochondrial pathway dependent platelet apoptosis, which leads to platelet clearance in vivo.

PKa activator can inhibit the apoptosis and clearance of platelets caused by different causes, increase the number of platelets in vivo and prolong the storage time of platelets in vitro. It is also confirmed that PKA regulates platelet apoptosis by regulating serine phosphorylation at 155 position of bad. The team also found that receptor interacting protein-3 (RIP3) regulates platelet function by selectively regulating thromboxane A2 and thrombin mediated platelet activation pathway.

matters needing attention

Blood test tube and syringe must be silicified. The platelet count of each test must be the same, otherwise the test results will be affected. When the platelet count is too low, the sensitivity of this method is low. This study provides a new theoretical basis for the diagnosis and treatment of platelet related diseases, platelet storage, and the solution of platelet related medical problems, and provides new targets and strategies for the development of antithrombotic drugs.