Steroid dermatitis?

summary

Corticosteroid dependent dermatitis, referred to as hormone dependent dermatitis, is caused by long-term repeated improper external use of hormones. In recent years, the incidence of corticosteroid dependent dermatitis is increasing year by year, and it is stubborn and difficult to cure, which has become the focus of medical experts. Steroid dermatitis? Let's talk about it

Steroid dermatitis?

Local long-term external use of hormones, hormones by interfering with the differentiation of the epidermis, induce changes in skin structure and function, inhibit the proliferation of keratinocytes. It results in the decrease of the formation of clear cuticle granules and the thinning of cuticle. The thinning of dermis is due to the change of viscoelasticity of glycoprotein and proteoglycan, which weakens the adhesion between collagen fibrils and reduces the synthesis of collagen.

Due to the decrease in the number of layers of the stratum corneum, the melanin migrating to the keratinocytes decreases, causing hypopigmentation. Pigmentation may be related to glucocorticoid activating melanocyte to regenerate pigment. The decrease of the adhesion between the collagen fibers in the vascular wall can lead to the widening of the vessels and the disappearance of the dermal collagen, which leads to the exposure of the surface vessels.

In hormone induced rosacea like lesions, the density of Demodex follicularis increased significantly. Demodex follicularis blocked the outlet of sebaceous glands of hair follicles, acted as a carrier of bacteria, causing inflammation or allergy. Powerful hormone can also make sebaceous glands proliferate, leading to a unique rosacea like rash. Hormone can make hair follicle epithelial degeneration, leading to outlet blocked, acne like rash or make the original acne worse.

matters needing attention

Patients during treatment must pay attention to taboo, many hormone dependent dermatitis is caused by skin allergy, or skin inflammation, misuse of hormones. Allergic constitution, skin inflammation is often aggravated by certain foods, hormone dependent dermatitis will be the same, will make the disease worse, prolong the treatment time. For example, eating mutton, drinking alcohol and spicy food can aggravate facial rash. Therefore, we warn such patients that spicy food, seafood, fish, shrimp, crab, beef and mutton, and even leek and fennel are taboo.