Can biguanides cause ketonuria

summary

Biguanidine is a kind of drug with strong efficacy, which may cause constipation or other adverse reactions. It is harmful to human body. Now let's talk about whether biguanides can cause ketonuria.

Can biguanides cause ketonuria

First: biguanide hypoglycemic drugs do great harm to the gastrointestinal tract, easily lead to dyspepsia, and may lead to ketonuria and lactic acidosis in severe cases. Adverse reactions: loss of appetite, bitter mouth, metallic taste, nausea, vomiting, diarrhea and other gastrointestinal reactions. Rare but severe ketonuria or lactic acidemia may occur.

Second: function and use: it has hypoglycemic effect on diabetic patients with or without islet beta cell function, but has no effect on normal people. It can inhibit the absorption of glucose by intestinal parietal cells, increase the uptake and utilization of glucose by skeletal muscle and surrounding tissues (anaerobic digestion), increase the uptake of glucose by liver cells, improve the sensitivity of target tissues to insulin, inhibit the release of glucagon or inhibit the effect of insulin antagonists. It is mainly used in obese patients with type 2 diabetes or unsuccessful diet control.

Third: contraindications are forbidden for pregnant women and lactating women. Alcohol addicts, liver, kidney and lung dysfunction, heart failure, any systemic hypoxia are forbidden. 3. Patients with ketoacidosis, pre coma diabetes or complicated infection, acute fever are also prohibited. Pay attention to the adverse drug reactions. It is not suitable for patients with diabetic acidosis or lactic acidosis.

matters needing attention

The patients who use biguanide hypoglycemic drugs should take the drugs under the doctor's prescription. The contraindications can not be taken at will, which is easy to have serious sequelae. Drugs can not be taken at will, to take symptomatic in the doctor's advice, to prevent adverse consequences.