What medicine does paralytic dementia take?

summary

Paralytic dementia is a clinical manifestation of late syphilis caused by Treponema pallidum invading the brain. It is characterized by nerve paralysis, progressive dementia and personality disorder. The late manifestation of neurosyphilis is caused by organic damage of central nervous system. Positive serological tests and characteristic CSF changes contribute to the diagnosis. Juvenile paralytic dementia is a kind of congenital syphilis, which usually appears at about 10 years old. The disease is also known as general paralysis, general paralysis dementia. What medicine does paralytic dementia take?

What medicine does paralytic dementia take?

This disease is caused by Treponema pallidum invading the brain parenchyma, leading to brain atrophy. The most prominent pathological changes in the frontal lobe are brain atrophy, degeneration of nerve cells, loss of cortical structure disorder, which may also lead to mental symptoms of dementia.

Mental symptoms (1) in the early stage, neurasthenia syndrome was the most common, followed by personality changes, mental retardation, mental retardation, emotional depression and increased low-level intention（ 2) The progressive stage is mainly characterized by the increasingly serious mental and personality disorders, which are often manifested as the decline of perception, attention, memory, calculation, thinking and other intelligent activities, personality change, dishonesty, irresponsibility, frivolous and uninhibited behavior, selfishness, stinginess, profligacy, theft or violation of social morality, delusional state, emotional irritability or forced crying and laughing（ 3) In the late stage, dementia became more and more serious, with apathy, wrong intention and hyperactivity of instinct.

Penicillin is the most effective drug in the treatment of GPI. Jarish-Herxheimer reaction is sometimes seen during treatment, and the incidence rate is high in GPI patients. The symptoms include influenza like symptoms within a few hours to 24 hours after the first injection of penicillin, rising body temperature, general discomfort, aggravation of syphilis damage, deterioration of syphilis symptoms in internal organs and central nervous system, which can be life-threatening. If necessary, prednisone should be taken orally before treatment. Combined with AIDS to use large doses of penicillin.

matters needing attention

Once GPI is established, it will develop rapidly. It will fall into a state of disability in terms of intelligence and social activities. In the late stage, it is also powerless in terms of physical strength. If not treated, they will die within three years. Dementia caused by syphilis is a treatable dementia, so early diagnosis is of great significance. The basic measures to prevent syphilis are to strengthen the knowledge of prevention, publicity and education, and to actively treat syphilis patients.